High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements

**Semantic type:** Neoplastic Process

**Definition:** High-grade B-cell lymphoma characterized by the abnormal rearrangement of MYC gene, BCL2 gene, and BCL6 gene. Patients with this type of lymphoma usually respond poorly to standard treatments and have a poor prognosis.

**Synonyms:** - HGBCL-TH - High-Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements - Triple Hit Lymphoma - Triple-Hit Lymphoma - Triple-Hit Lymphoma