Diffuse Large B-Cell Lymphoma

**Semantic type:** Neoplastic Process

**Definition:** A non-Hodgkin lymphoma characterized by a diffuse proliferation of predominantly large neoplastic B lymphocytes. It is the most frequently seen type of non-Hodgkin lymphoma, representing 30%-40% of the cases. Morphologic variants include centroblastic lymphoma, immunoblastic lymphoma, and anaplastic lymphoma. Subtypes/entities include T-cell/histiocyte rich large B-cell lymphoma, primary diffuse large B-cell lymphoma of the central nervous system, plasmablastic lymphoma, primary cutaneous diffuse large B-cell lymphoma, leg type, and ALK-positive large B-cell lymphoma.

**Synonyms:** - DLBCL - Diffuse Large B-Cell Lymphoma (DLBCL) - Diffuse large B-cell lymphoma - Diffuse large B-cell lymphoma, unspecified site - Non-follicular (diffuse) lymphoma, unspecified, unspecified site - diffuse large B-cell lymphoma