Depudecin

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** Depudecin is a fungal metabolite that reverts the rounded phenotype of NIH 3T3 fibroblasts transformed with v-ras and v-src oncogenes to the flattened phenotype of the non-transformed parental cells. The mechanism of de-transformation induced by this agent had not been determined. However, depudecin has been demonstrated to inhibit histone deacetylase (HDAC) activity effectively both in vivo and in vitro.

**Synonyms:** - (2R,3S,4S,5E,7S,8S,9R)-2,9- Dihydroxy-3,4;7,8-diepoxy-undeca-5,10-diene - (2S-(2R*(E(2R*(S*),3R*)),3R*(S*)))-alpha-Ethenyl-3-(2-(3-(1-hydroxyethyl)oxiranyl)ethenyl)oxiranemethanol - Oxiranemethanol, Alpha-ethenyl-3-(2-(3-(1-hydroxyethyl) oxiranyl)ethenyl)-, (2S- (2R*(E(2R*(S*),3R*)),3R*(S*)))-