Menogaril

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** A semisynthetic derivative of the anthracycline antineoplastic antibiotic nogalamycin. Menogaril intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin. (NCI04)

**Synonyms:** - 7(R)-O-Methylnogarol - 7-(R)-O-methylnogarol - 7-OMEN - 7-OMEN - 7-con-O-Methylnogarol - 7-con-O-methylnogarol - 7-con-O-methylnorgarol - MEN - MENOGARIL - MENOGARIL - Menogarol - OMEN,7- - TUT-7 - U-52047 - U-52047 - [2R-(2alpha,3beta,4alpha,5beta,6alpha,11alpha,13alpha)]-4-(dimethylamino)-3,4,5,6,11,12,13,14-octahydro-3,5,8,10,13-pentahydroxy-11-methoxy-6,13-dimethyl-2,6-epoxy-2H-naphthaceno[1,2-b]oxocin-9,16-dione