Peplomycin

**Semantic type:** Amino Acid, Peptide, or Protein|Antibiotic|Pharmacologic Substance

**Definition:** A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04)

**Synonyms:** - (S)-n1-[3-[(1-phenylethyl)amino]propyl]bleomycinamide - PEP - PEPLEOMYCIN - PEPLOMYCIN - Pepleomycin - n1-[3[[(S)-alpha-methylbenzyl]amino]propyl]bleomycinamide