BRCA1 Biallelic Inactivation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** The presence of mutations in both alleles of the BRCA1 gene that either lead to loss of expression of the BRCA1 protein or result in the translation of an inactive BRCA1 protein.

**Synonyms:** - BRCA1 Biallelic Gene Inactivation - BROVCA1 Biallelic Gene Inactivation - Breast Cancer 1 Biallelic Gene Inactivation - Breast Cancer 1, Early Onset Biallelic Gene Inactivation - Breast Cancer Type 1 Susceptibility Biallelic Gene Inactivation