Tumor Suppressor Gene Inactivation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of a tumor suppressor gene that results in decreased expression or activity for the encoded protein.

**Synonyms:** - Tumor Suppressor Gene Inactivating Mutation - Tumor Suppressor Loss of Function Gene Mutation - Tumor Suppressor Loss of Function Mutation - Tumor-Suppressor Gene Inactivation