Ivospemin Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt form of ivospemin, an analogue of naturally occurring polyamine (PA), with potential antineoplastic activity. Upon subcutaneous administration, ivospemin displaces endogenous PAs from PA-binding sites on the cell surface, which prevents internalization of PA. This inhibits PA-dependent cell cycle processes and results in cell cycle arrest, the induction of apoptosis, and inhibition of tumor cell proliferation. PA uptake is upregulated in various tumor types and increased levels of PA leads to enhanced tumor cell growth.

**Synonyms:** - Diethyl Dihydroxyhomospermine - HO2-DEHSPM - IVOSPEMIN HYDROCHLORIDE - Polyamine Analogue SBP-101 - SBP 101 Tetrahydrochloride - SBP-101 Tetrahydrochloride