Nolatrexed

**Semantic type:** Pharmacologic Substance

**Definition:** A water-soluble lipophilic quinazoline folate analog, with antineoplastic activity. Upon administration, nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. Nolatrexed also exhibits radiosensitizing activity.

**Synonyms:** - 2-Amino-6-methyl-5-(4-pyridylthio)-4(3H)-quinazolinone - NOLATREXED