NY-ESO-1 TCR Retroviral Vector-transduced Autologous PBMCs

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** Human autologous peripheral blood mononuclear cells (PBMCs) transduced with a retroviral vector (RV) encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NY-ESO-1 TCR RV-transduced autologous PBMCs recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types.

**Synonyms:** - Autologous RV-NY-ESO-1 TCR PBMC - Autologous RV-NYESO TCR PBMC - Engineered Autologous PBMC Expressing NY-ESO-1 TCR - NY-ESO-1 Reactive TCR Retroviral Vector Transduced Autologous PBMCs - NY-ESO-1 T-cell Receptor-engineered Peripheral Blood Mononuclear Cells - NY-ESO-1 TCR-transduced Autologous PBMCs