T-cell Receptor-engineered T-cells

**Semantic type:** Chemical Viewed Functionally

**Definition:** T-lymphocytes that have been engineered to express a modified antigen-specific T-cell receptor (TCR). In cancer therapy, the TCR-engineered T-cell recognizes a tumor-specific protein fragment complexed with major histocompatibility complex (MHC) molecules on the surface of the tumor cells and kills the tumor cell.

**Synonyms:** - T-cell Receptor-engineered T Cells - T-cell Receptor-engineered T-lymphocytes - TCR T Cells - TCR T-cells - TCR-engineered T-cells - TCR-modified T Cells