Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes

**Semantic type:** Neoplastic Process

**Definition:** Molecular subtyping of diffuse large B-cell lymphomas (DLBCL) based on structural genomic abnormalities and gene expression data obtained from biopsy samples. The molecular analysis revealed four subtypes of DLBCL (MCD, BN2, N1, and EZB) which have distinct genotypic, epigenetic, and clinical characteristics. (NEJM 2018; 378: 1396-407)

**Synonyms:** - DLBCL, NOS Genetic Subtypes - DLBCL, NOS Molecular Subtypes - Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Genetic Subtypes