Pleckstrin Homology Domain-Containing Family G Member 5

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Pleckstrin homology domain-containing family G member 5 (1062 aa, ~117 kDa) is encoded by the human PLEKHG5 gene. This protein plays a role in the activation of transforming protein RhoA and nuclear factor kappa B signaling pathways.

**Synonyms:** - GEF720 - Guanine Nucleotide Exchange Factor 720 - PH Domain-Containing Family G Member 5 - PLEKHG5 - Pleckstrin Homology Domain- and RhoGEF Domain-Containing Protein G5 - Pleckstrin Homology Domain-Containing Protein, Family G. Member 5 - Synectin-Binding Guanine Exchange Factor