Guanine Nucleotide Exchange Factor

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Proteins that catalyze the release and exchange of GDP for GTP from GTP-binding regulatory proteins, which are active in the GTP-bound form.

**Synonyms:** - GDP Exchange Factors - GDP-GTP Exchange Factors - GEF - Guanine Nucleotide-Exchange Factor - Guanine Nucleotide-Releasing Factor - Guanyl-Nucleotide Exchange Factor - Guanyl-Nucleotide Releasing Factor