Losoxantrone

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An anthrapyrazole-based antineoplastic antibiotic. Losoxantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Losoxantrone is less cardiotoxic than doxorubicin.

**Synonyms:** - Biantrazole - Biantrazole - CI-941 - CI-941 - DuP 941 - LOSOXANTRONE - losoxantrone