Vonoprazan

**Semantic type:** Pharmacologic Substance

**Definition:** A potassium-competitive acid blocker (P-CAB), with acid suppressing activity. Upon oral administration, vonoprazan concentrates in the gastric parietal cells and competitively and reversibly binds to the potassium binding site of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. By inhibiting gastric acid secretion, vonoprazan provides relief and healing in the treatment of various conditions, such as gastroduodenal ulcers and reflux esophagitis.

**Synonyms:** - VONOPRAZAN