Actinium Ac 225 Rosopatamab Tetraxetan

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A radioimmunoconjugate consisting of a humanized monoclonal antibody directed against prostate specific membrane antigen (PSMA) labeled with the alpha particle-emitting radioisotope actinium Ac-225, with potential antineoplastic activity. Upon administration, actinium Ac 225 rosopatamab tetraxetan binds to the extracellular domain of PSMA with high affinity, thereby delivering alpha radiation to PSMA expressing cells. PSMA, a type II membrane protein expressed in all types of prostatic tissues, is often overexpressed in tumor cells.

**Synonyms:** - 225Ac-J591 - Ac 225 MOAB J591 - Ac 225 Monoclonal Antibody J591 - Actinium Ac-225 Anti-PSMA Monoclonal Antibody J591 - Actinium Ac-225 Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody J591