Pegylated Liposomal Doxorubicin Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** A liposome-encapsulated preparation of the hydrochloride salt of the anthracycline antineoplastic antibiotic doxorubicin. Doxorubicin intercalates between DNA base pairs, thereby hinders the movement of replication machinery along DNA strands, as well as blocks the activity of topoisomerase II during replication. As a result, this agent causes DNA adducts formation, renders single- and double-stranded DNA breakages that induce DNA repair and or apoptotic processes. Doxorubicin also generates reactive oxygen species that leads to cytotoxicity secondary to lipid peroxidation of cell membrane lipids. Liposomal delivery of doxorubicin HCl improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects. A liposomal formulation of doxorubicin also modulates toxicity, specifically the cardiac effects commonly seen with anthracycline antitumor drugs.

**Synonyms:** - (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-tri-hydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride - ATI-0918 - Caelyx - DOX-SL - DOXIL - Dox-SL - Doxil - Doxil - Doxilen - Doxorubicin HCl Liposomal - Doxorubicin HCl Liposome - Doxorubicin Hydrochloride Liposome - Doxorubicin Liposomal - Doxorubicin Liposomal - Duomeisu - Evacet - Evacet - LipoDox - LipoDox - Lipodox 50 - Liposomal Adriamycin - Liposomal Doxorubicin Hydrochloride - Liposomal-Encapsulated Doxorubicin - Pegylated Doxorubicin HCl Liposome - Pegylated Liposomal Doxorubicin - Pegylated liposomal doxorubicin - S-Liposomal Doxorubicin - Stealth Liposomal Doxorubicin - TLC D-99 - doxorubicin hydrochloride liposome - liposomal doxorubicin hydrochloride