Thorium Th 227 Anetumab Corixetan

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A radioimmunoconjugate consisting of anetumab, a human immunoglobulin G1 (IgG1) monoclonal antibody directed against the cell surface glycoprotein mesothelin, conjugated to the chelating agent corixetan, and labeled with the alpha-emitting radioisotope thorium Th 227, with potential antineoplastic activity. Upon administration of thorium Th 227 anetumab corixetan, the anetumab moiety binds to the tumor-associated antigen (TAA) mesothelin, delivering a cytotoxic dose of alpha radiation to cells expressing mesothelin.

**Synonyms:** - 227Th Anetumab Corixetan - ANETUMAB CORIXETAN THORIUM TH-227 - BAY 2287411 - BAY2287411 - Thorium Th 227 Monoclonal Antibody BAY2287411 - Thorium-227 Labeled Anetumab - Thorium-227 Labeled Antibody-chelator Conjugate BAY2287411