Ubl Carboxyl-Terminal Hydrolase 18

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Ubl carboxyl-terminal hydrolase 18 (372 aa, ~43 kDa) is encoded by the human USP18 gene. This protein plays a role in the modulation of type I interferon-dependent signaling through the cleavage of ubiquitin-like protein ISG15 conjugated-proteins.

**Synonyms:** - 43 kDa ISG15-Specific Protease - EC 3.4.19.- - ISG15-Specific-Processing Protease - USP18 - Ubiquitin Specific Peptidase 18 - Ubiquitin Specific Protease 18 - Ubiquitin Thioesterase 18 - Ubiquitin-Specific Peptidase 18 - Ubiquitin-Specific Protease 18 - Ubl Thiolesterase 18 - hUBP43