Alvocidib Hydrochloride

**Semantic type:** Pharmacologic Substance

**Definition:** The hydrochloride salt form of alvocidib, a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.

**Synonyms:** - (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride - 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5, 7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, (-)-cis- - ALVOCIDIB HYDROCHLORIDE - Flavopiridol Hydrochloride - HL-275 - HMR 1275 - HMR 1275 - HMR-1275 - HMR1275 - L 868275 - L-86-8275 - L-868275 - L868275 - MDL 107,826A - MDL-107826A