Fostroxacitabine Bralpamide

**Semantic type:** Pharmacologic Substance

**Definition:** A liver-targeting nucleotide phosphoramidate prodrug of troxacitabine monophosphate (TRX-MP), a dioxolane derivative and L-configuration deoxycytidine analogue, with potential antineoplastic activity. Upon oral administration, fostroxacitabine bralpamide is rapidly and specifically hydrolyzed in hepatocytes by liver carboxylesterase 1 (carboxylesterase 1, CE-1), generating high levels of the chain-terminating nucleotide, troxacitabine triphosphate (TRX-TP) in the liver. TRX-TP is then incorporated into tumor cell DNA, leading to termination of DNA synthesis and inhibition of tumor cell proliferation.

**Synonyms:** - FOSTROXACITABINE BRALPAMIDE - MIV 818 - MIV-818 - MIV818 - Troxacitabine Nucleotide Prodrug MIV-818 - Troxacitabine Prodrug MIV-818