Actinium Ac 225-FPI-1434

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A radioconjugate consisting of veligrotug, a humanized monoclonal antibody directed against insulin-like growth factor-1 receptor (IGF-1R) linked, via a bifunctional chelate, to the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic activity. Upon administration of actinium Ac 225-FPI-1434, the veligrotug moiety targets and binds to IGF-1R expressed on tumor cells. Upon binding, the radioisotope moiety delivers a cytotoxic dose of alpha radiation to IGF-1R-expressing tumor cells. Activation of IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by various cancer cell types, stimulates cell proliferation, promotes angiogenesis, enables oncogenic transformation, and suppresses apoptosis.

**Synonyms:** - 225Ac-FPI-1434 - Actinium Ac 225-FPI-1397-FPI-1175 - Actinium Ac 225-labeled FPI-1434 - FPI 1434 - FPI-1434 - FPI1434 - FPX 01 - FPX-01 - FPX01 - [225Ac]-FPI-1434 - [Ac-225]-FPI-1434