Bocodepsin Besylate

**Semantic type:** Pharmacologic Substance

**Definition:** The besylate form of bocodepsin, an orally bioavailable inhibitor of the histone deacetylase (HDAC) subtypes 1 and 4, with potential antineoplastic activity. Upon administration,bocodepsin targets, binds to and inhibits the activity of HDAC1/4. This results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This consequently results in a selective transcription of tumor suppressor genes, tumor suppressor protein-mediated inhibition of tumor cell division and an induction of apoptosis in tumor cells that overexpress HDAC1/4. HDAC, which is upregulated in many tumor cell types, deacetylates chromatin histone proteins and plays a key role in transcriptional regulation and cell cycle progression.

**Synonyms:** - BOCODEPSIN BESYLATE - Class 1/4 Histone Deacetylase Inhibitor OKI-179 - Class-1/4 HDACi OKI-179 - HDAC Inhibitor OKI-179 - HDAC1/4i OKI-179 - HDACi 1/4 OKI-179 - HDACi OKI-179 - OKI 179 - OKI-179 - OKI179