LMB-7 Immunotoxin

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells. The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2. (NCI04)

**Synonyms:** - B3(Fv)-PE38 - B3(Fv)-PE38 Immunotoxin - HB21(Fv)PE40 - Immunotoxin LMB-7 - Immunotoxin LMB-7 - LMB-7 (Single-Chain Immunotoxin) - LMB-7 immunotoxin