Pseudomonas Exotoxin Immunoconjugate

**Semantic type:** Chemical Viewed Functionally

**Definition:** An immunotoxin containing epitope of Pseudomonas exotoxin (PE) with immunotherapeutic property. PE, a peptide toxin of 613 amino acids, consists of 3 functional domains: an amino-terminal receptor-binding domain, a middle translocation domain, and a carboxyl-terminal ADP-ribosylation domain. The last 5 carboxyl-terminal amino acids, Arg-Glu-Asp-Leu-Lys, are critical for its cytotoxic action.

**Synonyms:** - PE Immunoconjugate - Pseudomonas aeruginosa Exotoxin A Conjugate