Becatecarin

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04)

**Synonyms:** - 1,11-Dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione - 5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)- - BECATECARIN - BMS-181176 - BMY-27557-14 - DEAE-Rebeccamycin - NSC 655649 - Rebeccamycin Analogue - Rebeccamycin Analogue, Tartrate Salt - Rebeccamycin analog - XL119 - rebeccamycin analog