Oncogene CSF1R

**Semantic type:** Gene or Genome

**Definition:** Human colony stimulating factor 1 receptor (CSF1R) gene, located at 5q33.2-q33.3, encodes macrophage colony stimulating factor I receptor protein. Mutations in this gene have been detected in both chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. One out of fifty hematologically normal individuals exhibit a CSFR1 variant allele (Y969C) that may cause a predisposition to myeloid malignancy.

**Synonyms:** - Oncogene FMS