Amyloid-Beta Precursor Protein

**Semantic type:** Amino Acid, Peptide, or Protein|Receptor

**Definition:** Amyloid-beta precursor protein (770 aa, ~87 kDa) is encoded by the human APP gene. This protein is involved in cell surface receptor-mediated signaling and is processed by secretases into soluble peptides, membrane-anchored fragments, plaque amyloid components, transcriptional regulatory molecules and neurotoxic fragments.

**Synonyms:** - AAA - ABPP - APP - APP - APPI - Alzheimer Disease 1 Protein - Alzheimer Disease Amyloid A4 Protein Homolog - Alzheimer Disease Amyloid Protein - Alzheimer's Disease Amyloid Protein - Amyloid - Amyloid Beta (A4) Precursor Protein - Amyloid Beta A4 Protein - Amyloid Beta A4 Protein - Amyloid Beta A4 Protein Precursor - Amyloid Beta-Peptide - Amyloid Precursor Protein - Amyloid of Aging and Alzheimer Disease Protein - Amyloid-Beta (A4) Precursor Protein - Amyloid-Beta A4 Protein - CVAP - Cerebral Vascular Amyloid Peptide - Cerebralvascular Amyloid Peptide - PN II - PN-II - PN2 - PreA4 - Protease Nexin II - Protease Nexin-II - Protease Nexin-II, Alzheimer Disease