EGFR Exon 20 Tyrosine Kinase Inhibitor Resistant Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A molecular genetic abnormality indicating the presence of secondary mutations in exon 20 of the EGFR gene that result in the translation of an epidermal growth factor receptor protein that is resistant to tyrosine kinase inhibitor therapies.

**Synonyms:** - EGFR Exon 20 Resistance Mutation - EGFR Exon 20 TKI-Resistant Mutation - ERBB Exon 20 TKI-Resistant Mutation - ERBB1 Exon 20 TKI-Resistant Mutation - Epidermal Growth Factor Receptor Gene Exon 20 TKI-Resistant Mutation - HER1 Exon 20 TKI-Resistant Mutation