Astatine At 211 Anti-CD38 Monoclonal Antibody OKT10-B10

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A radioimmunoconjugate composed of the anti-CD38 monoclonal antibody (MoAb) OKT10-B10 labeled with the alpha-emitting radionuclide astatine (At) 211 (211At), with potential antineoplastic activity. Upon administration of astatine At 211 anti-CD38 MoAb OKT10-B10, the MoAb moiety targets and binds to CD38-expressing tumor cells, thereby delivering a cytotoxic dose of alpha radiation directly to the CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein and tumor-associated antigen (TAA), is present on various immune cells and in hematologic malignancies; its expression has been correlated with poor prognosis.

**Synonyms:** - 211At-OKT10-B10 - Astatine 211-labeled Anti-CD38 Monoclonal Antibody OKT10-B10 - Astatine At 211 Anti-CD38 MoAb OKT10-B10 - Astatine-211-OKT10-B10 - At211-OKT10-B10 - [211At]OKT10-B10