Romaciclib Hydrochloride

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The hydrochloride salt form of romaciclib, an orally bioavailable inhibitor of cyclin-dependent kinases 8 and 19 (CDK8/19), with potential antineoplastic and chemoprotective activities. Upon oral administration, romaciclib targets, binds to and inhibits the activity of CDK8/19, which prevents activation of CDK8/19-mediated oncogenic signaling pathways, blocks selective transcription of various tumor-promoting genes, and inhibits proliferation of CDK8/19-overexpressing tumor cells. CDK8/19, serine/threonine kinases involved in the regulation of the cell cycle, are overexpressed in certain cancer cell types and play key roles in tumor cell proliferation.

**Synonyms:** - 4H-Imidazo(4,5,1-ij)quinoline, 7,8-dibromo-5,6-dihydro-9-methyl-2-(1-piperazinyl)-, Hydrochloride - 6,7-Dibromo-5-methyl-2-piperazin-1-yl-1,3-diazatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraene;hydrochloride - 7,8-Dibromo-5,6-dihydro-9-methyl-2-(1-piperazinyl)-4Himidazo(4,5,1-ij)quinoline Hydrochloride - CDK8/19 Inhibitor RVU120 - CDK8/19 Inhibitor SEL 120 - RVU 120 - RVU-120 - RVU120 - SEL 120 - SEL 120-34 - SEL 120-34A - SEL-120 - SEL-120 - SEL120