Trabectedin

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia turbinata with potential antineoplastic activity. Binding to the minor groove of DNA, trabectedin interferes with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks and blocks the cell cycle in the G2 phase.

**Synonyms:** - ET 743 - ET-743 - ET-743 - ET743 - Ecteinascidin - Ecteinascidin 743 - Ecteinascidin 743 - Spiro(6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo(7,8)isoquino(3,2,-b)(3)benzazocine-20,1'(2'H)-isoquinolin)-19-one, 3',4',6,6a,7,13,14,16-Octahydro-5-(acetyloxy)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-, (6R-(6-alpha,6a-beta,7-beta,13-beta,14-beta,16-alpha,20R*))- - TRABECTEDIN - Yondelis - Yondelis - ecteinascidin 743 - trabectedin