Tissue-Type Plasminogen Activator

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Tissue-type plasminogen activator (562 aa, ~63 kDa) is encoded by the human PLAT gene. This protein plays a role in the cleavage of plasminogen between Arg-580 and Val-581 to form the fibrinolytic enzyme plasmin.

**Synonyms:** - EC 3.4.21.68 - PLAT - T-Plasminogen Activator - TPA - Tissue Plasminogen Activator - t-PA - tPA - tissue plasminogen activator