Nelarabine

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04)

**Synonyms:** - 2-Amino, 6-Methoxypurine Arabinoside - 2-Amino-6-methoxypurine arabinoside - 2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine - 506U78 - 506U78 - Arranon - Arranon - Compound 506U78 - GW506U78 - NELARABINE - nelarabine