Oncogene ABL1

**Semantic type:** Gene or Genome

**Definition:** Human v-abl Abelson murine leukemia viral oncogene homolog 1 (ABL1) gene, located at 9q34.1, encodes proto-oncogene tyrosine-protein kinase ABL1 protein. Alternative splicing of this gene produces two protein isoforms. A t(9;22) translocation, resulting in the fusion of the BCR and ABL1 genes, has been detected in many cases of chronic myelogeneous leukemia.. This BCR-ABL fusion gene is also present in acute myeloid leukemia and acute lymphoblastic leukemia.

**Synonyms:** - ABL - Abelson Murine Leukemia Viral Oncogene Homolog - Oncogene, ABL - Oncogene, ABL1 - v-ABL - v-abl