Protein Tyrosine Phosphatase

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Encoded by Protein Tyrosine Phosphatase Genes, Protein Tyrosine Phosphatases are a group of enzymes that specifically remove tyrosine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase. Together with protein tyrosine kinases, Tyrosine Phosphatases regulate tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. (NCI)

**Synonyms:** - PPT-Phosphatase - PTP-Phosphatase - PTPase - PTPs - Phosphoprotein Phosphatase (Phosphotyrosine) - Phosphotyrosine Phosphatase - Phosphotyrosine Protein Phosphatase - Phosphotyrosylprotein Phosphatase - Protein Phosphotyrosine Phosphatase - Protein-Tyrosine-Phosphatase - Tyrosine O-Phosphate Phosphatase - Tyrosine-Specific Protein Phosphatase - Tyrosylprotein Phosphatase - [Phosphotyrosine]Protein Phosphatase