E3 Ubiquitin-Protein Ligase MDM2

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** E3 ubiquitin-protein ligase Mdm2 (491 aa, ~55 kDa) is encoded by the human MDM2 gene. This protein is involved in the mediation of the ubiquitination and degradation of protein substrates, and the inhibition of apoptosis induction that is mediated by cellular tumor antigen p53.

**Synonyms:** - Double Minute 2 Protein - EC 2.3.2.27 - HDM2 - MDM 2 Protein - MDM2 - MDM2 Protein - Oncoprotein Mdm2 - RING-Type E3 Ubiquitin Transferase Mdm2 - Ubiquitin-Protein Ligase E3 MDM2 - p53 Binding Protein - p53-Binding Protein MDM2