E3 Ubiquitin-Protein Ligase Itchy Homolog

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** E3 ubiquitin-protein ligase Itchy homolog (903 aa, ~103 kDa) is encoded by the human ITCH gene. This protein is involved in the regulation of inflammation through the ubiquitination of inflammatory pathway proteins.

**Synonyms:** - AIP4 - Atrophin-1 Interacting Protein 4 - Atrophin-1-Interacting Protein 4 - Atrophin-1-Interacting Protein-4 - EC 2.3.2.26 - HECT-Type E3 Ubiquitin Transferase Itchy Homolog - ITCH - Itchy E3 Ubiquitin Protein Ligase - Itchy E3 Ubiquitin Protein Ligase Homolog - NAPP1 - NFE2-Associated Polypeptide 1