Activating MET Exon 14 Skipping Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the MET gene that that results in loss of transcription of MET exon 14 and constitutive activation of hepatocyte growth factor receptor and its downstream signaling pathways.

**Synonyms:** - Activating HGFR Exon 14 Skipping Mutation - Activating HGFR Exon 14 Splice Mutation - Activating Hepatocyte Growth Factor Receptor Exon 14 Skipping Mutation - Activating MET Exon 14 Deletion Mutation - Activating MET Exon 14 Splice Mutation - Activating MET Proto-Oncogene, Receptor Tyrosine Kinase Exon 14 Skipping Mutation - Activating c-MET Exon 14 Deletion Mutation - Activating c-MET Exon 14 Splice Mutation - Activating c-Met Exon 14 Skipping Alteration - Activating c-Met Exon 14 Skipping Mutation - MET Exon 14 Skipping Gain of Function Gene Mutation - MET Exon 14 Skipping Gain of Function Mutation