PAX/FOXO1 Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene resulting from a chromosomal translocation that fuses a PAX family gene (usually PAX3 or PAX7, on chromosome 2 or 1, respectively) with the FOXO1 gene on chromosome 13. These rearrangements result in expression of fusion proteins consisting of the intact PAX family N-terminal DNA binding domain fused in-framed to the intact FOXO1 C-terminal transcriptional activation domain and are associated with alveolar rhabdomyosarcoma.

**Synonyms:** - PAX Family/FOXO1 Fusion Gene - PAX Family/Forkhead Box O1 Gene Fusion - PAX-FOXO1 Fusion Gene - PAX/FKHR Fusion Gene - PAX/Forkhead Box O1 Gene Fusion - PAX::FOXO1 Fusion Gene