D2-40 IHC Staining Method

**Semantic type:** Laboratory Procedure

**Definition:** An immunohistochemical technique utilizing the mouse monoclonal IgG1 antibody D2-40, which is directed against the human O-linked sialoglycoprotein podoplanin (PDPN). D2-40 specifically binds to PDPN, a protein that is selectively expressed in normal lymphatic endothelium as well as in vascular lesions of lymphatic origin. This staining method can detect aberrant expression of lymphatic epithelium, which is associated with lymphangioma, Kaposi sarcoma, epithelioid mesothelioma and seminoma.

**Synonyms:** - Anti-PDPN D2-40 Staining Method - Anti-Podoplanin D2-40 Staining Method - Antibody D2-40 Staining Method - D2-40 - D2-40 Antibody Staining Method - D2-40 Monoclonal Antibody - D2-40 Staining Method