HLA Class I Histocompatibility Antigen, Alpha Chain E

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** HLA class I histocompatibility antigen, alpha chain E (358 aa, ~40 kDa) is encoded by the human HLA-E gene. This protein is involved in binding to nonameric peptides derived from the signal sequences of MHC class Ia molecules and the modulation of the cytotoxic activity of natural killer cells.

**Synonyms:** - HLA-E - HLAE - MHC Class I Antigen E