Raltitrexed

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity. (NCI04)

**Synonyms:** - D1694 - ICI D1694 - ICI D1694 - N-(5-[N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl)-L-glutamic Acid - N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic Acid - RALTITREXED - ZD 1694 - ZD-1694 - ZD1694 - raltitrexed