Activating EGFR Exon 21 Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A molecular genetic abnormality indicating the presence of a mutation in exon 21 of the EGFR gene that results in constitutive epidermal growth factor receptor-dependent signal transduction and activation of downstream signaling pathways.

**Synonyms:** - Activating EGFR Exon 21 Gene Mutation - Activating ERBB Exon 21 Mutation - Activating ERBB1 Exon 21 Mutation - Activating Epidermal Growth Factor Receptor Exon 21 Mutation - Activating HER1 Exon 21 Mutation - EGFR Exon 21 Activating Gene Mutation - EGFR Exon 21 Activating Mutation - EGFR Exon 21 Gain of Function Gene Mutation - EGFR Exon 21 Gain of Function Mutation - Gain of Function EGFR Exon 21 Gene Mutation - Gain of Function EGFR Exon 21 Mutation