Activating EGFR Gene Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A somatic mutation of the epidermal growth factor receptor gene which encodes a constitutively active 170kDa transmembrane protein, a short transmembrane region, and an intracellular domain.

**Synonyms:** - Activating EGFR Mutation - Activating ERBB1 Mutation - Activating HER1 Mutation - Activating c-erbB1 Mutation - EGFR Activating Mutation - EGFR Activating Mutation - EGFR Gain of Function Gene Mutation - EGFR Gene Activation - Epidermal Growth Factor Receptor Activating Mutation - Epidermal Growth Factor Receptor Gene Activation