E3 Ubiquitin-Protein Ligase HUWE1

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** E3 ubiquitin-protein ligase HUWE1 (4374 aa, ~482 kDa) is encoded by the human HUWE1 gene. This protein is involved in the modulation of ubiquitination of target proteins involved in DNA replication and repair, apoptosis, chromatin remodeling, circadian rhythms and tumor suppression.

**Synonyms:** - ARF-BP1 - ARF-Binding Protein 1 - BJ-HCC-24 Tumor Antigen - EC 2.3.2.26 - HECT Domain Protein LASU1 - HECT, UBA and WWE Domain Containing 1 - HECT, UBA and WWE Domain Containing E3 Ubiquitin Protein Ligase 1 - HECT, UBA and WWE Domain-Containing Protein 1 - HECT, UBA, and WWE Domains-Containing Protein 1 - HECT-Type E3 Ubiquitin Transferase HUWE1 - HUWE1 - Homologous to E6AP Carboxyl Terminus Homologous Protein 9 - LASU1 - Large Structure of UREB1 - Mcl-1 Ubiquitin Ligase E3 - Mule - URE-B1 - URE-Binding Protein 1 - Upstream Regulatory Element-Binding Protein 1