Oncogene ROS

**Semantic type:** Gene or Genome

**Definition:** Highly-expressed in a variety of tumor cell lines, human Oncogene ROS is a mutated variant of ROS1 Gene, which belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The encoded type I integral membrane protein, Tyrosine-Protein Kinase ROS, with tyrosine kinase activity may function as a growth or differentiation factor receptor. Oncogene ROS1 disrupts normal cell function.

**Synonyms:** - Avian UR2 Sarcoma Virus Oncogene Homolog 1