Cilengitide

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI04)

**Synonyms:** - CILENGITIDE - EMD 121974 - EMD 121974 - EMD 121974 - EMD-121974 - cilengitide - cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl)