BL22 Immunotoxin

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody RFB4 fused to a fragment of Pseudomonas exotoxin-A with potential antineoplastic activity. BL22 immunotoxin binds to CD22, an antigen expressed in B-cell malignancies, thereby delivering its toxin directly to tumor cells. The toxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also blocks translational elongation via binding to elongation factor-2 in eukaryotic cells.

**Synonyms:** - Anti-CD22 Recombinant Immunotoxin BL22 - BL22 - BL22 Immunotoxin [RFB4(dsFv)-PE38] - BL22 immunotoxin - BL22 immunotoxin - CAT 3888 - CAT-3888 - CAT3888 - GCR 3888 - GCR-3888 - GCR3888 - Immunotoxin BL22 - RFB4(dsFv)-PE38 Immunotoxin